Coexpression cluster:C4084

Full id: C4084_peripheral_osteoclastoma_mesenchymal_Preadipocyte_Adipocyte_melanoma_bone

Phase1 CAGE Peaks

Hg19::chr21:46293545..46293584,-	p2@PTTG1IP
Hg19::chr21:46293586..46293641,-	p1@PTTG1IP
Hg19::chr21:46293644..46293655,-	p3@PTTG1IP

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
mesodermal cell	8.97e-27	119
embryonic cell	1.26e-21	248
lining cell	3.62e-18	57
barrier cell	3.62e-18	57
non-terminally differentiated cell	1.62e-17	180
meso-epithelial cell	2.83e-16	44
endothelial cell	1.66e-14	35
endothelial cell of vascular tree	1.20e-13	24
blood vessel endothelial cell	1.21e-10	18
embryonic blood vessel endothelial progenitor cell	1.21e-10	18
vascular associated smooth muscle cell	4.04e-10	32
epithelial cell	1.20e-09	254
animal cell	2.17e-09	679
eukaryotic cell	2.17e-09	679
somatic cell	2.24e-09	591
smooth muscle cell	1.76e-08	42
smooth muscle myoblast	1.76e-08	42
contractile cell	2.42e-08	59
muscle precursor cell	2.55e-08	57
myoblast	2.55e-08	57
multi-potent skeletal muscle stem cell	2.55e-08	57
muscle cell	2.49e-07	54
kidney cell	3.44e-07	18
kidney epithelial cell	3.44e-07	18

Uber Anatomy

Ontology term	p-value	n
epithelial tube	1.84e-25	118
vasculature	1.03e-23	79
vascular system	1.03e-23	79
vessel	2.44e-21	69
blood vessel	6.34e-19	60
epithelial tube open at both ends	6.34e-19	60
blood vasculature	6.34e-19	60
vascular cord	6.34e-19	60
splanchnic layer of lateral plate mesoderm	2.25e-18	84
cardiovascular system	1.52e-17	110
circulatory system	2.61e-17	113
multi-cellular organism	1.37e-15	659
unilaminar epithelium	1.83e-15	138
artery	1.83e-15	42
arterial blood vessel	1.83e-15	42
arterial system	1.83e-15	42
anatomical system	7.96e-13	625
trunk mesenchyme	1.20e-12	143
anatomical group	1.60e-12	626
trunk	6.90e-12	216
systemic artery	1.06e-11	33
systemic arterial system	1.06e-11	33
mesoderm	1.10e-11	448
mesoderm-derived structure	1.10e-11	448
presumptive mesoderm	1.10e-11	448
simple squamous epithelium	2.21e-11	22
squamous epithelium	2.65e-11	25
endothelium	1.21e-10	18
blood vessel endothelium	1.21e-10	18
cardiovascular system endothelium	1.21e-10	18
cell layer	1.67e-10	312
anatomical conduit	5.95e-10	241
epithelium	8.55e-10	309
anatomical cluster	3.77e-09	286
tube	3.98e-09	194
germ layer	1.22e-08	604
embryonic tissue	1.22e-08	604
presumptive structure	1.22e-08	604
epiblast (generic)	1.22e-08	604
lateral plate mesoderm	1.24e-08	216
embryonic structure	1.39e-08	605
developing anatomical structure	1.39e-08	605
embryo	7.20e-08	612
aorta	1.28e-07	21
aortic system	1.28e-07	21
skeletal muscle tissue	5.85e-07	61
striated muscle tissue	5.85e-07	61
myotome	5.85e-07	61
muscle tissue	6.47e-07	63
musculature	6.47e-07	63
musculature of body	6.47e-07	63
abdominal segment of trunk	8.99e-07	61
abdomen	8.99e-07	61

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.