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|gostat_on_coexpression_clusters=GO:0030824!negative regulation of cGMP metabolic process!0.000392480081635857!79849$GO:0030823!regulation of cGMP metabolic process!0.000392480081635857!79849$GO:0035003!subapical complex!0.000392480081635857!79849$GO:0030826!regulation of cGMP biosynthetic process!0.000392480081635857!79849$GO:0030827!negative regulation of cGMP biosynthetic process!0.000392480081635857!79849$GO:0030251!guanylate cyclase inhibitor activity!0.000392480081635857!79849$GO:0019934!cGMP-mediated signaling!0.00067282299709004!79849$GO:0030803!negative regulation of cyclic nucleotide biosynthetic process!0.000706464146944542!79849$GO:0030800!negative regulation of cyclic nucleotide metabolic process!0.000706464146944542!79849$GO:0030809!negative regulation of nucleotide biosynthetic process!0.000706464146944542!79849$GO:0007168!receptor guanylyl cyclase signaling pathway!0.00100923449563506!79849$GO:0030802!regulation of cyclic nucleotide biosynthetic process!0.00100923449563506!79849$GO:0045980!negative regulation of nucleotide metabolic process!0.00100923449563506!79849$GO:0030808!regulation of nucleotide biosynthetic process!0.00100923449563506!79849$GO:0030799!regulation of cyclic nucleotide metabolic process!0.00103026021429412!79849$GO:0030249!guanylate cyclase regulator activity!0.00103026021429412!79849$GO:0006140!regulation of nucleotide metabolic process!0.00112624719078115!79849$GO:0008200!ion channel inhibitor activity!0.00112624719078115!79849$GO:0016248!channel inhibitor activity!0.00112624719078115!79849$GO:0046068!cGMP metabolic process!0.00112624719078115!79849$GO:0006182!cGMP biosynthetic process!0.00112624719078115!79849$GO:0006833!water transport!0.00112624719078115!79849$GO:0042044!fluid transport!0.00112624719078115!79849$GO:0009636!response to toxin!0.00235488048981514!79849$GO:0016247!channel regulator activity!0.0033910279053338!79849$GO:0009190!cyclic nucleotide biosynthetic process!0.00362289306125406!79849$GO:0009187!cyclic nucleotide metabolic process!0.00428924660644901!79849$GO:0009890!negative regulation of biosynthetic process!0.00428924660644901!79849$GO:0008022!protein C-terminus binding!0.00600900538780416!79849$GO:0045177!apical part of cell!0.00675065740413673!79849$GO:0043296!apical junction complex!0.00772695160720593!79849$GO:0016327!apicolateral plasma membrane!0.00772695160720593!79849$GO:0019935!cyclic-nucleotide-mediated signaling!0.00870592181083174!79849$GO:0005911!intercellular junction!0.0119821860217065!79849$GO:0009889!regulation of biosynthetic process!0.0146002590368539!79849$GO:0009165!nucleotide biosynthetic process!0.0166804034695239!79849$GO:0019932!second-messenger-mediated signaling!0.0170569721964989!79849$GO:0007167!enzyme linked receptor protein signaling pathway!0.0185911617616985!79849$GO:0045934!negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0192617147756674!79849$GO:0009117!nucleotide metabolic process!0.0200164841634287!79849$GO:0055086!nucleobase, nucleoside and nucleotide metabolic process!0.0210790521893209!79849$GO:0031324!negative regulation of cellular metabolic process!0.0213621301576088!79849$GO:0004857!enzyme inhibitor activity!0.02196062968409!79849$GO:0030054!cell junction!0.0228161754124311!79849$GO:0009892!negative regulation of metabolic process!0.0228161754124311!79849$GO:0005829!cytosol!0.0290776547438044!79849$GO:0042221!response to chemical stimulus!0.0295111618830025!79849$GO:0005624!membrane fraction!0.0335079869696613!79849$GO:0000267!cell fraction!0.0433490245268012!79849
|gostat_on_coexpression_clusters=GO:0030824!negative regulation of cGMP metabolic process!0.000392480081635857!79849$GO:0030823!regulation of cGMP metabolic process!0.000392480081635857!79849$GO:0035003!subapical complex!0.000392480081635857!79849$GO:0030826!regulation of cGMP biosynthetic process!0.000392480081635857!79849$GO:0030827!negative regulation of cGMP biosynthetic process!0.000392480081635857!79849$GO:0030251!guanylate cyclase inhibitor activity!0.000392480081635857!79849$GO:0019934!cGMP-mediated signaling!0.00067282299709004!79849$GO:0030803!negative regulation of cyclic nucleotide biosynthetic process!0.000706464146944542!79849$GO:0030800!negative regulation of cyclic nucleotide metabolic process!0.000706464146944542!79849$GO:0030809!negative regulation of nucleotide biosynthetic process!0.000706464146944542!79849$GO:0007168!receptor guanylyl cyclase signaling pathway!0.00100923449563506!79849$GO:0030802!regulation of cyclic nucleotide biosynthetic process!0.00100923449563506!79849$GO:0045980!negative regulation of nucleotide metabolic process!0.00100923449563506!79849$GO:0030808!regulation of nucleotide biosynthetic process!0.00100923449563506!79849$GO:0030799!regulation of cyclic nucleotide metabolic process!0.00103026021429412!79849$GO:0030249!guanylate cyclase regulator activity!0.00103026021429412!79849$GO:0006140!regulation of nucleotide metabolic process!0.00112624719078115!79849$GO:0008200!ion channel inhibitor activity!0.00112624719078115!79849$GO:0016248!channel inhibitor activity!0.00112624719078115!79849$GO:0046068!cGMP metabolic process!0.00112624719078115!79849$GO:0006182!cGMP biosynthetic process!0.00112624719078115!79849$GO:0006833!water transport!0.00112624719078115!79849$GO:0042044!fluid transport!0.00112624719078115!79849$GO:0009636!response to toxin!0.00235488048981514!79849$GO:0016247!channel regulator activity!0.0033910279053338!79849$GO:0009190!cyclic nucleotide biosynthetic process!0.00362289306125406!79849$GO:0009187!cyclic nucleotide metabolic process!0.00428924660644901!79849$GO:0009890!negative regulation of biosynthetic process!0.00428924660644901!79849$GO:0008022!protein C-terminus binding!0.00600900538780416!79849$GO:0045177!apical part of cell!0.00675065740413673!79849$GO:0043296!apical junction complex!0.00772695160720593!79849$GO:0016327!apicolateral plasma membrane!0.00772695160720593!79849$GO:0019935!cyclic-nucleotide-mediated signaling!0.00870592181083174!79849$GO:0005911!intercellular junction!0.0119821860217065!79849$GO:0009889!regulation of biosynthetic process!0.0146002590368539!79849$GO:0009165!nucleotide biosynthetic process!0.0166804034695239!79849$GO:0019932!second-messenger-mediated signaling!0.0170569721964989!79849$GO:0007167!enzyme linked receptor protein signaling pathway!0.0185911617616985!79849$GO:0045934!negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process!0.0192617147756674!79849$GO:0009117!nucleotide metabolic process!0.0200164841634287!79849$GO:0055086!nucleobase, nucleoside and nucleotide metabolic process!0.0210790521893209!79849$GO:0031324!negative regulation of cellular metabolic process!0.0213621301576088!79849$GO:0004857!enzyme inhibitor activity!0.02196062968409!79849$GO:0030054!cell junction!0.0228161754124311!79849$GO:0009892!negative regulation of metabolic process!0.0228161754124311!79849$GO:0005829!cytosol!0.0290776547438044!79849$GO:0042221!response to chemical stimulus!0.0295111618830025!79849$GO:0005624!membrane fraction!0.0335079869696613!79849$GO:0000267!cell fraction!0.0433490245268012!79849
|id=C3094
|id=C3094
|ontology_enrichment_celltype=CL:0000738!5.20e-36!140;CL:0002031!1.07e-30!124;CL:0000037!1.35e-28!172;CL:0000566!1.35e-28!172;CL:0002032!2.27e-27!165;CL:0000837!2.27e-27!165;CL:0002087!2.40e-27!119;CL:0000988!2.22e-26!182;CL:0000542!1.57e-18!53;CL:0000051!1.57e-18!53;CL:0000838!1.77e-18!52;CL:0000766!1.24e-14!76;CL:0000557!5.72e-12!71;CL:0000839!6.96e-12!70;CL:0000763!6.98e-11!112;CL:0000049!6.98e-11!112;CL:0002009!3.44e-10!65;CL:0000084!5.44e-10!25;CL:0000827!5.44e-10!25;CL:0002194!2.81e-09!63;CL:0000576!2.81e-09!63;CL:0000040!2.81e-09!63;CL:0000559!2.81e-09!63;CL:0000791!4.18e-09!18;CL:0000789!4.18e-09!18;CL:0002420!4.18e-09!18;CL:0002419!4.18e-09!18;CL:0000790!4.18e-09!18;CL:0000945!1.79e-08!24;CL:0000826!1.79e-08!24;CL:0002057!2.27e-07!42;CL:0000625!5.62e-07!11
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002193!2.92e-19!112;UBERON:0002390!6.21e-19!102;UBERON:0003061!6.21e-19!102;UBERON:0002405!1.73e-12!115;UBERON:0007023!2.84e-10!115;UBERON:0002371!3.01e-10!80;UBERON:0001474!1.86e-08!86;UBERON:0000178!3.40e-08!15;UBERON:0000179!3.40e-08!15;UBERON:0000463!3.40e-08!15
}}
}}

Revision as of 14:32, 21 May 2012


Full id: C3094_rectum_small_colon_Eosinophils_temporal_appendix_CD4



Phase1 CAGE Peaks

Hg19::chr11:119056158..119056172,+p2@PDZD3
Hg19::chr1:2488426..2488475,-p1@LOC100133445
p1@LOC115110
Hg19::chr1:2488477..2488501,-p1@ENST00000452793


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0030824negative regulation of cGMP metabolic process0.000392480081635857
GO:0030823regulation of cGMP metabolic process0.000392480081635857
GO:0035003subapical complex0.000392480081635857
GO:0030826regulation of cGMP biosynthetic process0.000392480081635857
GO:0030827negative regulation of cGMP biosynthetic process0.000392480081635857
GO:0030251guanylate cyclase inhibitor activity0.000392480081635857
GO:0019934cGMP-mediated signaling0.00067282299709004
GO:0030803negative regulation of cyclic nucleotide biosynthetic process0.000706464146944542
GO:0030800negative regulation of cyclic nucleotide metabolic process0.000706464146944542
GO:0030809negative regulation of nucleotide biosynthetic process0.000706464146944542
GO:0007168receptor guanylyl cyclase signaling pathway0.00100923449563506
GO:0030802regulation of cyclic nucleotide biosynthetic process0.00100923449563506
GO:0045980negative regulation of nucleotide metabolic process0.00100923449563506
GO:0030808regulation of nucleotide biosynthetic process0.00100923449563506
GO:0030799regulation of cyclic nucleotide metabolic process0.00103026021429412
GO:0030249guanylate cyclase regulator activity0.00103026021429412
GO:0006140regulation of nucleotide metabolic process0.00112624719078115
GO:0008200ion channel inhibitor activity0.00112624719078115
GO:0016248channel inhibitor activity0.00112624719078115
GO:0046068cGMP metabolic process0.00112624719078115
GO:0006182cGMP biosynthetic process0.00112624719078115
GO:0006833water transport0.00112624719078115
GO:0042044fluid transport0.00112624719078115
GO:0009636response to toxin0.00235488048981514
GO:0016247channel regulator activity0.0033910279053338
GO:0009190cyclic nucleotide biosynthetic process0.00362289306125406
GO:0009187cyclic nucleotide metabolic process0.00428924660644901
GO:0009890negative regulation of biosynthetic process0.00428924660644901
GO:0008022protein C-terminus binding0.00600900538780416
GO:0045177apical part of cell0.00675065740413673
GO:0043296apical junction complex0.00772695160720593
GO:0016327apicolateral plasma membrane0.00772695160720593
GO:0019935cyclic-nucleotide-mediated signaling0.00870592181083174
GO:0005911intercellular junction0.0119821860217065
GO:0009889regulation of biosynthetic process0.0146002590368539
GO:0009165nucleotide biosynthetic process0.0166804034695239
GO:0019932second-messenger-mediated signaling0.0170569721964989
GO:0007167enzyme linked receptor protein signaling pathway0.0185911617616985
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0192617147756674
GO:0009117nucleotide metabolic process0.0200164841634287
GO:0055086nucleobase, nucleoside and nucleotide metabolic process0.0210790521893209
GO:0031324negative regulation of cellular metabolic process0.0213621301576088
GO:0004857enzyme inhibitor activity0.02196062968409
GO:0030054cell junction0.0228161754124311
GO:0009892negative regulation of metabolic process0.0228161754124311
GO:0005829cytosol0.0290776547438044
GO:0042221response to chemical stimulus0.0295111618830025
GO:0005624membrane fraction0.0335079869696613
GO:0000267cell fraction0.0433490245268012



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte5.20e-36140
hematopoietic lineage restricted progenitor cell1.07e-30124
hematopoietic stem cell1.35e-28172
angioblastic mesenchymal cell1.35e-28172
hematopoietic oligopotent progenitor cell2.27e-27165
hematopoietic multipotent progenitor cell2.27e-27165
nongranular leukocyte2.40e-27119
hematopoietic cell2.22e-26182
lymphocyte1.57e-1853
common lymphoid progenitor1.57e-1853
lymphoid lineage restricted progenitor cell1.77e-1852
myeloid leukocyte1.24e-1476
granulocyte monocyte progenitor cell5.72e-1271
myeloid lineage restricted progenitor cell6.96e-1270
myeloid cell6.98e-11112
common myeloid progenitor6.98e-11112
macrophage dendritic cell progenitor3.44e-1065
T cell5.44e-1025
pro-T cell5.44e-1025
monopoietic cell2.81e-0963
monocyte2.81e-0963
monoblast2.81e-0963
promonocyte2.81e-0963
mature alpha-beta T cell4.18e-0918
alpha-beta T cell4.18e-0918
immature T cell4.18e-0918
mature T cell4.18e-0918
immature alpha-beta T cell4.18e-0918
lymphocyte of B lineage1.79e-0824
pro-B cell1.79e-0824
CD14-positive, CD16-negative classical monocyte2.27e-0742
CD8-positive, alpha-beta T cell5.62e-0711
Uber Anatomy
Ontology termp-valuen
hemolymphoid system2.92e-19112
hematopoietic system6.21e-19102
blood island6.21e-19102
immune system1.73e-12115
adult organism2.84e-10115
bone marrow3.01e-1080
bone element1.86e-0886
blood3.40e-0815
haemolymphatic fluid3.40e-0815
organism substance3.40e-0815


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.