Coexpression cluster:C2169

Full id: C2169_large_neuroectodermal_neuroblastoma_carcinoid_cerebellum_pineal_occipital

Phase1 CAGE Peaks

Hg19::chr11:83436366..83436383,-	p27@DLG2
Hg19::chr15:69373184..69373197,+	p2@LINC00277
Hg19::chr15:69373210..69373239,+	p1@LINC00277
Hg19::chr5:132948193..132948209,-	p1@FSTL4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004385	guanylate kinase activity	0.012949936385265
GO:0019201	nucleotide kinase activity	0.0223591816075259
GO:0016776	phosphotransferase activity, phosphate group as acceptor	0.0267512822343677
GO:0019205	nucleobase, nucleoside, nucleotide kinase activity	0.0267512822343677
GO:0045211	postsynaptic membrane	0.0315202427647414
GO:0044456	synapse part	0.0315202427647414

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
central nervous system	2.80e-35	82
regional part of nervous system	2.35e-34	94
nervous system	2.35e-34	94
neural tube	3.72e-33	57
neural rod	3.72e-33	57
future spinal cord	3.72e-33	57
neural keel	3.72e-33	57
regional part of brain	1.93e-30	59
adult organism	5.02e-29	115
brain	1.78e-28	69
future brain	1.78e-28	69
neurectoderm	9.35e-27	90
regional part of forebrain	1.63e-26	41
forebrain	1.63e-26	41
future forebrain	1.63e-26	41
anterior neural tube	1.71e-25	42
neural plate	1.65e-23	86
presumptive neural plate	1.65e-23	86
telencephalon	5.81e-21	34
gray matter	8.84e-21	34
brain grey matter	8.84e-21	34
regional part of telencephalon	4.26e-20	33
cerebral hemisphere	7.91e-20	32
neocortex	2.22e-18	20
pre-chordal neural plate	8.74e-18	61
ectoderm	1.19e-17	173
presumptive ectoderm	1.19e-17	173
regional part of cerebral cortex	1.39e-17	22
ectoderm-derived structure	2.18e-15	169
cerebral cortex	1.89e-14	25
pallium	1.89e-14	25
anterior region of body	4.13e-14	129
craniocervical region	4.13e-14	129
head	1.44e-13	123
anatomical cluster	1.05e-11	286
tube	1.12e-10	194
anatomical conduit	7.02e-09	241
organ part	8.05e-09	219
posterior neural tube	9.70e-09	15
chordal neural plate	9.70e-09	15
larynx	2.46e-08	9
basal ganglion	4.17e-08	9
nuclear complex of neuraxis	4.17e-08	9
aggregate regional part of brain	4.17e-08	9
collection of basal ganglia	4.17e-08	9
cerebral subcortex	4.17e-08	9
nucleus of brain	6.49e-08	9
neural nucleus	6.49e-08	9
temporal lobe	1.14e-07	7
segmental subdivision of hindbrain	4.22e-07	12
hindbrain	4.22e-07	12
presumptive hindbrain	4.22e-07	12
respiratory primordium	4.36e-07	38
endoderm of foregut	4.36e-07	38
diencephalon	4.43e-07	7
future diencephalon	4.43e-07	7
gyrus	6.14e-07	6

Disease

Ontology term	p-value	n
cell type cancer	2.94e-08	143
germ cell and embryonal cancer	4.32e-08	22
germ cell cancer	4.32e-08	22
neuroectodermal tumor	8.86e-08	10

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.