Coexpression cluster:C1117

Full id: C1117_CD19_Eosinophils_Dendritic_Neutrophils_Basophils_CD14_CD34

Phase1 CAGE Peaks

Hg19::chr10:43932296..43932360,+	p1@ZNF487P
Hg19::chr22:50629895..50629908,-	p@chr22:50629895..50629908 -
Hg19::chr22:50630977..50630984,-	p@chr22:50630977..50630984 -
Hg19::chr22:50639164..50639182,-	p@chr22:50639164..50639182 -
Hg19::chr2:64880894..64880977,-	p2@SERTAD2
Hg19::chr3:135914798..135914850,+	p@chr3:135914798..135914850 +
Hg19::chr5:40681669..40681698,+	p4@PTGER4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004957	prostaglandin E receptor activity	0.0254229767174927
GO:0030278	regulation of ossification	0.0254229767174927
GO:0004955	prostaglandin receptor activity	0.0254229767174927
GO:0046850	regulation of bone remodeling	0.0254229767174927
GO:0004953	icosanoid receptor activity	0.0254229767174927
GO:0004954	prostanoid receptor activity	0.0254229767174927
GO:0030308	negative regulation of cell growth	0.0344450048876544
GO:0045792	negative regulation of cell size	0.0344450048876544
GO:0048856	anatomical structure development	0.0344450048876544
GO:0045926	negative regulation of growth	0.0344450048876544
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0354795642737389
GO:0019933	cAMP-mediated signaling	0.0354795642737389
GO:0031214	biomineral formation	0.0354795642737389
GO:0001503	ossification	0.0354795642737389
GO:0046849	bone remodeling	0.0361203882202558
GO:0048771	tissue remodeling	0.0370325943749413
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0382378355329935
GO:0019935	cyclic-nucleotide-mediated signaling	0.0382378355329935
GO:0001558	regulation of cell growth	0.0465793516965004
GO:0032502	developmental process	0.0465793516965004
GO:0003713	transcription coactivator activity	0.0471036744921992
GO:0016049	cell growth	0.0471036744921992
GO:0040008	regulation of growth	0.0471036744921992
GO:0008361	regulation of cell size	0.0471036744921992
GO:0001501	skeletal development	0.0471036744921992
GO:0045893	positive regulation of transcription, DNA-dependent	0.0483159197004316

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.37e-52	140
hematopoietic stem cell	2.20e-50	172
angioblastic mesenchymal cell	2.20e-50	172
hematopoietic cell	1.48e-47	182
hematopoietic oligopotent progenitor cell	5.64e-46	165
hematopoietic multipotent progenitor cell	5.64e-46	165
hematopoietic lineage restricted progenitor cell	9.13e-41	124
nongranular leukocyte	5.75e-40	119
myeloid leukocyte	1.20e-28	76
myeloid cell	1.75e-27	112
common myeloid progenitor	1.75e-27	112
granulocyte monocyte progenitor cell	3.10e-25	71
CD14-positive, CD16-negative classical monocyte	3.59e-22	42
macrophage dendritic cell progenitor	4.97e-22	65
myeloid lineage restricted progenitor cell	7.99e-22	70
monopoietic cell	6.15e-21	63
monocyte	6.15e-21	63
monoblast	6.15e-21	63
promonocyte	6.15e-21	63
classical monocyte	1.04e-18	45
lymphoid lineage restricted progenitor cell	6.19e-17	52
lymphocyte	1.74e-16	53
common lymphoid progenitor	1.74e-16	53
mesenchymal cell	2.96e-13	358
connective tissue cell	3.74e-13	365
motile cell	3.04e-10	390
mature alpha-beta T cell	5.40e-09	18
alpha-beta T cell	5.40e-09	18
immature T cell	5.40e-09	18
mature T cell	5.40e-09	18
immature alpha-beta T cell	5.40e-09	18
T cell	9.54e-09	25
pro-T cell	9.54e-09	25
B cell	1.37e-08	14
lymphocyte of B lineage	7.67e-08	24
pro-B cell	7.67e-08	24
intermediate monocyte	3.29e-07	9
CD14-positive, CD16-positive monocyte	3.29e-07	9
granulocyte	8.79e-07	8

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	1.73e-31	102
blood island	1.73e-31	102
hemolymphoid system	5.70e-31	112
bone marrow	3.14e-23	80
bone element	4.84e-22	86
immune system	1.51e-17	115
skeletal element	2.60e-17	101
skeletal system	2.60e-17	101
connective tissue	2.00e-12	375
adult organism	1.30e-08	115
blood	5.71e-08	15
haemolymphatic fluid	5.71e-08	15
organism substance	5.71e-08	15

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.