Coexpression cluster:C618

Full id: C618_skeletal_heart_left_diaphragm_throat_skin_maxillary

Phase1 CAGE Peaks

Hg19::chr10:919094..919101,-	p@chr10:919094..919101 -
Hg19::chr10:919161..919172,-	p@chr10:919161..919172 -
Hg19::chr18:3219935..3219940,-	p5@MYOM1
Hg19::chr19:3950387..3950398,+	p@chr19:3950387..3950398 +
Hg19::chr20:33565724..33565728,+	p3@MYH7B
Hg19::chr2:179494327..179494343,-	p@chr2:179494327..179494343 -
Hg19::chr2:179494358..179494367,-	p@chr2:179494358..179494367 -
Hg19::chr2:179494375..179494392,-	p@chr2:179494375..179494392 -
Hg19::chr2:179494404..179494433,-	p@chr2:179494404..179494433 -
Hg19::chr2:179665435..179665442,-	p@chr2:179665435..179665442 -
Hg19::chr5:191638..191646,+	p9@LRRC14B
Hg19::chr6:73471730..73471745,+	p@chr6:73471730..73471745 +
Hg19::chr7:123241658..123241669,-	p@chr7:123241658..123241669 -
Hg19::chr8:124665994..124666002,-	p@chr8:124665994..124666002 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016459	myosin complex	0.000402943405822179
GO:0015629	actin cytoskeleton	0.00155109408377679
GO:0044430	cytoskeletal part	0.00772230272679474
GO:0032982	myosin filament	0.00772230272679474
GO:0005863	striated muscle thick filament	0.00772230272679474
GO:0005859	muscle myosin complex	0.00891040668937179
GO:0016460	myosin II complex	0.00891040668937179
GO:0005856	cytoskeleton	0.00891040668937179
GO:0006941	striated muscle contraction	0.00991794678464657
GO:0008307	structural constituent of muscle	0.0101316428173755
GO:0030017	sarcomere	0.010525451995305
GO:0030016	myofibril	0.0106525809272849
GO:0044449	contractile fiber part	0.0110240654734831
GO:0043292	contractile fiber	0.0110240654734831
GO:0043234	protein complex	0.0178123998291474
GO:0043232	intracellular non-membrane-bound organelle	0.0178123998291474
GO:0043228	non-membrane-bound organelle	0.0178123998291474
GO:0003012	muscle system process	0.0209109374396495
GO:0006936	muscle contraction	0.0209109374396495
GO:0032991	macromolecular complex	0.0267761009008234
GO:0044446	intracellular organelle part	0.0275376365500003
GO:0044422	organelle part	0.0275376365500003
GO:0003779	actin binding	0.0456705904149696

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.